Multiple system atrophy cerebellar variant: pathological implications of the neural connectivity
DOI:
https://doi.org/10.28957/rcmfr.354Keywords:
Multi-system atrophy, alpha-synuclein, cerebellar ataxia, default mode network, diffusion-weighted magnetic resonance imagingAbstract
Introduction. Multiple system atrophy (MSA) is a progressive neurodegenerative disease primarily affecting white matter (WM). This type of atrophy is characterized by causing glial cytoplasmic inclusions of the alpha-synuclein protein and decreasing the integrity, demyelination, and changes in the axonal diameter (movement disorders).
Objective. To evaluate the pathological findings of connectivity found in cases of Multiple system atrophy-cerebellar subtype (MSA-C) and the possible connections that these show with clinical signs, the pathophysiology of the disease, imaging and therapeutic targets through a systematic review of the available scientific literature.
Methods. A bibliographic search was carried out in the PubMed, ResearchGate, Embase, and Scopus databases with the following key terms: “Multiple system atrophy” AND “therapy” OR “diagnostic imagining” OR “physiopathology”
OR “epidemiology.” Articles were selected in Spanish and English and published between 1989 and 2022. After apply-
ing the inclusion and exclusion criteria and eliminating duplicates, 61 studies were selected that compared the study’s
target topics.
Results. Decreased functional connectivity in the left executive control network (ECN), related to the circuits of the
basal ganglia and thalamus, causes cerebellar-prefrontal and cerebellar-amygdaloid/parahippocampal disconnection,
which has neuro histopathological manifestations that are correlated with specific imaging findings.
Conclusion. It was evident that the results of various studies have made it possible to give viability to the understanding
of the identified nodal connectivity and its anatomical-pathological and functional manifestations in the natural course
of MSA-C.
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