Are the regenerative medicine, the key in treatment of osteoarthritis?
Keywords:
osteoarthritis, regeneration, tissue therapy, stem cells, growth factors.Abstract
Objective: to evaluate the usefulness of tissue regeneration technology available and the use of autologous stem cells in the treatment of injuries resulting from degenerative osteoarthritis in the hyaline cartilage of large joints.Methods: in the external consultation of Physiatrist at the Clínica Meta (Villavicencio, Colombia), we chose 10 patients with clinical diagnosis, x-ray classify the commitment of osteoarthritis in joints (knees). Stratified functional compromise to the visual analogue pain scale, and measurement of joint mobility. In addition to functional testing and a functional independence measure (WOMAC).
All patients received conventional therapy consisting of analgesics, joint-saving techniques and articulate low-impact aerobic exercise, but five of them were added in parallel, a local tissue activation protocol by articular injection technique, developed by Tissue Regeneration Institute in Colombia, called Cytogel®, every 15 days for two months (4 doses) and monitoring to six months. After the cases were reevaluated by
the same clinical tests and x-ray images.
The results suggest interesting and promising changes in terms of control of the underlying disease and clinical and functional improvement in patients with the protocol addressed.
References
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10. Mow VC, Ratcliffe A, Rosenwasser MP, Buckwalter JA. Experimental studies on repair of large osteochondral defects at a high weight bearing area of the knee joint: a tissue engineering study. J Biomech Eng 1991;113:198-20.
11. Alsousou J. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery. The Journal Of Bone & Joint Surgery 2009;91-B(8):993-994.
12. Pietrzak W. Musculoskeletal Tissue Regeneration. Biological Materials and Methods. Humana Press, 2008.
13. Dohan D, et al. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyteand platelet-rich fibrin (L-PRF). Trends in Biotechnology 2008;27(3).
14. Anuita E. Delivering growth factors for therapeutics. TRENDS in Pharmacological Sciences 2007;29(1).
15. Restrepo E. Fibrina. Artículo no publicado.
16. Alsousou J. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery. The Journal Of Bone & Joint Surgery 2009; 91-B(8):991-992.
17. Restrepo E. Cytogel, matriz multimolecular regenerativa. Monografía, IRT, 2009.
2. Curl WW, Krome J, Gordon ES, Rushing J, Smith BP, Poehling GG. Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy 1997;13:456-460.
3. Newman AP. Articular cartilage repair. Am J Sports Med 1998;26:309-324.
4. Hubbard MJ. Articular debridement versus washout for degeneration of the medial femoral condyle. A five-year study. J Bone Joint Surg Br 1996;78:217-219.
5. Minas T, Peterson L. Advanced techniques in autologous chondrocyte transplantation. Clin Sports Med 1999;18:13-44.
6. Peterson L, Brittberg M, Kiviranta I, Akerlund EL, Lindahl A. Autologous chondrocyte transplantation. Biomechanics and long-term durability. Am J Sports Med 2002;30:2-12.
7. Peterson L, Minas T, Brittberg M, Nilsson A, Sjögren-Jansson E, Lindahl A. Twoto 9- year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop 2000;212-234.
8. Marlovits S, Zeller P, Singer P, Resinger C, Vecsei V. Cartilage repair: generations of autologous chondrocyte transplantation. Eur J Radiol 2006;57:24-31.
9. Buckwalter JA, Mankin HJ. Articular cartilage: tissue design and Chondrocytematrix interactions. Instr Course Lect 1998;47:477-86.
10. Mow VC, Ratcliffe A, Rosenwasser MP, Buckwalter JA. Experimental studies on repair of large osteochondral defects at a high weight bearing area of the knee joint: a tissue engineering study. J Biomech Eng 1991;113:198-20.
11. Alsousou J. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery. The Journal Of Bone & Joint Surgery 2009;91-B(8):993-994.
12. Pietrzak W. Musculoskeletal Tissue Regeneration. Biological Materials and Methods. Humana Press, 2008.
13. Dohan D, et al. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyteand platelet-rich fibrin (L-PRF). Trends in Biotechnology 2008;27(3).
14. Anuita E. Delivering growth factors for therapeutics. TRENDS in Pharmacological Sciences 2007;29(1).
15. Restrepo E. Fibrina. Artículo no publicado.
16. Alsousou J. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery. The Journal Of Bone & Joint Surgery 2009; 91-B(8):991-992.
17. Restrepo E. Cytogel, matriz multimolecular regenerativa. Monografía, IRT, 2009.
How to Cite
1.
Gómez Huertas WA, Restrepo Restrepo E, Arias Guzmán M. Are the regenerative medicine, the key in treatment of osteoarthritis?. Rev. Colomb. Med. Fis. Rehabil. [Internet]. 2012 Apr. 14 [cited 2024 May 18];21(1):41-8. Available from: https://revistacmfr.org/index.php/rcmfr/article/view/7
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