Dolor músculo esquelético y vitamina D

  • Fabio Salinas D. Profesor Titular, Facultad de Medicina, Grupo Investigación Rehabilitación en Salud, Universidad de Antioquia, Colombia
Palabras clave: Dolor músculo esquelético, vitamina D, dolor crónico, mialgia

Resumen

La vitamina D aparte de su papel en la salud ósea, interviene en la excitabilidad neuronal, la percepción y modulación del dolor, los niveles de citoquinas pro inflamatorias y la salud del disco intervertebral.
Existe evidencia tanto a favor como en contra, de la asociación de los niveles bajos de VD con ciertos padecimientos dolorosos musculo esqueléticos crónicos y de la utilidad de administrar suplementos de esta vitamina. El presente artículo pretende presentar una parte de esta evidencia disponible, así como las recomendaciones de tratamiento y los síntomas de intoxicación en casos de sobredosis de VD.

Descargas

La descarga de datos todavía no está disponible.

Referencias bibliográficas

1. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85:752-7.

2. Heath KM, Elovic EP: Vitamin D deficiency: implications in the rehabilitation setting. Am J Phys Med Rehabil 2006; 85:916–923.

3. Von Kanel R, Muller-Hartmannsgruber V, Kokinogenis G, Egloff N. Vitamin D and central hypersensitivity in patients with chronic pain. Pain Med. 2014;15:1609–18.

4. Brown J, Bianco JI, McGrath JJ, Eyles DW. 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci Lett. 2003;343:139–43.

5. Shipton EA, Shipton EE. Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities. Pain Res Treat.

2015;2015:904967. Epub 2015 Apr 19. 6. Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer. 2007;7:684–700.

7. Brannon PM. Key questions in vitamin D research. Scand J Clin Lab Invest Suppl. 2012;243:154–62.

8. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrin Metab. 2010;95:471–8.

9. Matossian-Motley DL, Drake DA, Samimi JS, Camargo CA Jr, Quraishi SA. Association Between Serum 25(OH)D Level and Nonspecific Musculoskeletal Pain in Acute Rehabilitation Unit Patients JPEN J Parenter Enteral Nutr. 2014 Oct 14. pii: 0148607114555909. [Epub ahead of print]

10. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of Vitamin D receptor and 1a-hydroxylase in human brain. J Chem Neuroanat 2005;29:21–30.

11. Sedighi M, Haghnegahdar A. Role of vitamin D3 in treatment of lumbar disc herniation -pain and sensory aspects: study protocol for arandomized controlled trial. Trials. 2014 Sep 25;15:373. doi: 10.1186/1745-6215-15-373.

12. Kalb S, Martirosyan NL, Kalani MY, Broc GG, Theodore N. Genetics of the degenerated intervertebral disc. World Neurosurg. 2012;77:491-501.

13. S. Muraki, et al. Association of vitamin D status with knee pain and radiographic knee osteoarthritis. Osteoarthritis and Cartilage. 2011;19: 1301-1306

14. Russell JA: Osteomalacic myopathy. Muscle Nerve 1994;17: 578–80 15. Stroud ML, Stilgoe S, Stott VE, Alhabian O, Salman K. Vitamin D: a review. Australian Family Physician. 2008;37:1002-5.

16. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-281.

17. Meyer C. Scientists probe role of vitamin D: deficiency a significant problem, experts say. JAMA. 2004; 292:1416-7.

18. McBeth J, Pye SR, O’Neill TW, Macfarlane GJ, Tajar A, Bartfai G, et al. Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study. Ann Rheum Dis. 2010; 69:1448-1452

19. Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78:1463-70

20. Abbasi M, Hashemipour S, Hajmanuchehri F, Kazemifar AM. Is vitamin D deficiency associated with non specific musculoskeletal pain? Glob J Health Sci. 2012;5:107-11.

21. Heidari B, Shirvani JS, Firouzjahi A, Heidari P, Hajian-Tilaki KO. Association between nonspecific skeletal pain and vitamin D deficiency. Int J Rheum Dis. 2010;13:340-6.

22. Huang W, Shah S, Long Q, Crankshaw AK, Tangpricha V. Improvement of pain, sleep,and quality of life in chronic pain patients with vitamin D supplementation. Clin J Pain. 2013;29:341-7.

23. von Känel R, Müller-Hartmannsgruber V, Kokinogenis G, Egloff N. Vitamin D and central hypersensitivity in patients with chronic pain. Pain Med. 2014 ;15:1609-18.

24. Le Goaziou MF, Kellou N, Flori M, Perdrix C, Dupraz C, Bodier E, Souweine G.Vitamin D supplementation for diffuse musculoskeletal pain: Results of a before-and-after study Eur J Gen Pract. 2014;20:3-9.

25. Hirani V, Blyth FM, Naganathan V, Cumming RG, Le Couteur DG, Handelsman DJ, Waite LM, Seibel MJ.Active Vitamin D (1,25 Dihydroxyvitamin D) Is Associated With Chronic Pain in Older Australian Men: The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2015;70:387-95.

26. Kuru P, Akyuz G, Yagci I, Giray E. Hypovitaminosis D in widespread pain: its effect on pain perception, quality of life and nerve conduction studies. Rheumatol Int. 2015 ;35:315-22.

27. Schreuder F, Bernsen RM, van der Wouden JC. Vitamin supplementation for nonspecific musculoskeletal pain in non-Western immigrants: a randomized controlled trial. Ann Fam Med. 2012;10:547- 5.

28. Schwalfenberg G. Improvement of Chronic Back Pain or Failed Back Surgery with Vitamin D Repletion: A Case Series J Am Board Fam Med 2009;22:69 –74

29. Kim TH, Lee BH, Lee HM, Lee SH, Park JO, Kim HS, Kim SW, Moon SH.Prevalence of vitamin D deficiency in patients with lumbar spinal stenosis and its relationship with pain. Pain Physician. 2013;16:165-76.

30. Al Mutairi K, Al Faraj S. Vitamin D deficiency and chronic low back pain in Saudi Arabia Spine (Phila Pa 1976). 2003;28:177-9.

31. Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H.A randomized double-blind placebo- controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus. 2015;24:483-9.

32. Morioka TY, Lee AJ, Bertisch S, Buettner C. Vitamin D status modifies the association between statin use and musculoskeletal pain: a population based study. Atherosclerosis. 2015;238:77-82.

33. Ahmed W, Khan N, Glueck CJ, Pandey S, Wang P, Goldenberg N, Uppal M, Khanal S. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res. 2009;153:11-6.

34. Michalska-Kasiczak M, Sahebkar A, Mikhailidis DP, Rysz J, Muntner P, Toth PP, et al. Analysis of vitamin D levels in patients with and without statin-associated myalgia — A systematic review and meta-analysis of 7 studies with 2420 patients. Int J Cardiol. 2015;178:111-6

35. Vehapoglu A, Turel O, Turkmen S, Inal BB, Aksoy T, Ozgurhan G, Ersoy M. Are Growing Pains Related to Vitamin D Deficiency? Efficacy of Vitamin D Therapy for Resolution of Symptoms Med Princ Pract. 2015;24:332-8.

36. Oh R, Johnson J. Chest Pain and Costochondritis Associated with Vitamin D Deficiency: A Report of Two Cases Case Reports in Medicine Volume 2012 (2012), Article ID 375730, 3 pages http://dx.doi. org/10.1155/2012/375730 37. Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med. 2008;168:771-2.

38. Chao YS, Ekwaru JP, Ohinmaa A, Griener G, Veugelers PJ. Vitamin D and health- related quality of life in a community sample of older Canadians. Qual Life Res. 2014;23:2569-75.

39. Bergman P, Sperneder S, Höijer J, Bergqvist J, Björkhem-Bergman L. Low vitamin D levels are associated with higher opioid dose in palliative cancer patients-results from an observational study in Sweden. PLoS One.

2015 May 27;10(5):e0128223. doi: 10.1371/journal.pone.0128223. eCollection 2015.

40. Wepner F, Scheuer R, Schuetz-Wieser B, Machacek P, Pieler-Bruha E, Cross HS, Hahne J, Friedrich M. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. Pain. 2014;155:261-8.

41. Sheikh A, Saeed Z, Jafri SAD, Yazdani I, Hussain SA Vitamin D Levels in Asymptomatic Adults-A Population Survey in Karachi, Pakistan. PLoS ONE (2012) 7(3): e33452. doi:10.1371/journal.pone.0033452

42. Sandoughi M, Zakeri Z, Mirhosainee Z, Mohammadi M, Shahbakhsh S. The effect of vitamin D on nonspecific low back pain. Int J Rheum Dis. 2013 Oct 14. doi: 10.1111/1756- 185X.12172. [Epub ahead of print]

43. Kanukula R, Gudala K, Bansal D, Ghai B. Comment on: the effect of vitamin D on non-specific low back pain. Int J Rheum Dis. 2014;17:820-1

44. Kurnik D, Hochman I, Vesterman-Landes J, Kenig T, Katzir I, Lomnicky Y, Halkin H, Loebstein R. Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins. Clin Endocrinol (Oxf). 2012;77:36-41.

45. Al-Jarallah K, Shehab D, Abraham M, Mojiminiyi OA, Abdella NA. Musculoskeletal pain: should physicians test for vitamin D level? Int J Rheum Dis. 2013;16:193-7.

46. Turner MK, Hooten WM, Schmidt JE, Kerkvliet JL, Townsend CO, Bruce BK. Prevalence and clinical correlates of vitamin D inadequacy among patients with chronic pain. Pain Med. 2008;9:979-84.

47. de Rezende Pena C, Grillo LP, das Chagas Medeiros MM. Evaluation of 25-hydroxyvitamin D serum levels in patients with fibromyalgia. J Clin Rheumatol 2010;16:365-9.

48. Straube S, Derry S, Straube C, Moore RA. Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database of Systematic Reviews 2015, Issue 5. Art. No.: CD007771. DOI: 10.1002/14651858. CD007771.pub3.

49. Warner AE, Arnspiger SA. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol. 2008;14:12-6.

50. Knutsen KV, Madar AA, Brekke M, Meyer HE, Natvig B, Mdala I, Lagerløv P. Effect of vitamin D on musculoskeletal pain and headache: A randomized, double-blind, placebo- controlled trialamong adult ethnic minorities in Norway. Pain. 2014;155:2591-8.

51. McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, Lo G, Dawson- Hughes B. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309:155-62.

52. Shipton EE, Shipton EA. Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States. Pain Ther.2015; 4: 67- 87

53. Ministry of Health.[internet] . Ontario: Health Insurance Programs: Vitamin D; 2010 [actualizado dia del mes del año; consultado el dia del mes del año]. Disponible en: http://www.health.gov.on.ca/en/public/programs/ohip/changes/vitamin_d. aspx

54. Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001;73:288–94.

55. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S–6S.

56. Hollis BW, Wagner CL. Clinical review: the role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes. J Clin Endocrin Metab. 2013;98:4619–28.

57. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77:204–10.

58. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–81.

59. Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr. 2007;85:6-18.
Cómo citar
Salinas D., F. (1). Dolor músculo esquelético y vitamina D. Revista Colombiana De Medicina Física Y Rehabilitación, 25(2), 134-143. https://doi.org/10.28957/rcmfr.v25n2a3
Sección
Artículos de revisión