Brainsteem infiltration in advanced hematological malignancies; clinical features and diagnostic approach
DOI:
https://doi.org/10.28957/rcmfr.v28n2a6Keywords:
Neurolymphomatosis, brainsteem, cranial nerves, electrodiagnosis, diagnostic imaging.Abstract
The brainsteem and cranial nerves involvement secondary to progression of oncological diseases is an infrequent entity, that has a high risk for functional loss. The clinical evolution varies according to the nature of the diagnosis and the neural structure affected. The hematological malignancies have a high risk of progression to the brainstem where they infiltrate the cranial nerves, this process is called neurolymphomatosis. The purpose of this article is to describe the clinical manifestations of cranial nerve involvement secondary to the brainstem infiltration, in order to provide diagnostic elements that facilitate the orientation of the diagnostic and therapeutic interventions in rehabilitation, through the development of case reports and a brief review of the literature. Brainsteem infiltration in advanced hematological malignancies; clinical features and diagnostic approach.References
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2. Jiménez Zapata HD, Rojas Medina LM, Carrasco Moro R, Martínez Rodrigo A, García-Cosio Piqueras M. Cauda equina syndrome secondary to neurolymphomatosis: Case report and literature review. Neurocirugia [Internet]. 2017;29(3):138-42. Available from: http://dx.doi.org/10.1016/
j.neucir.2017.07.001
3. Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH. Neurolymphomatosis 1. Neuro Oncol. 2003;(April):104-15. http://dx.doi.org/10.1093/neuonc/nop021
4. Grisariu S, Avni B, Batchelor TT, Bent MJ Van Den, Bokstein F, Schiff D, et al. Neurolymphomatosis.: an International Primary CNS Lymphoma Collaborative Group report. 2016;115(24):5005-12. http: //dx.doi.org/10.1182/blood-2009-12-258210
5. Tomita M, Koike H, Kawagashira Y, Iijima M, Adachi H, Taguchi J, et al. Clinicopathological features of neuropathy associated with lymphoma. Brain. 2013;136(8):2563-78. http://dx.doi.org/10.1093/brain/awt193
6. Palma JA, Fernandez-Torron R, Esteve-Belloch P, Fontes-Villalba A, Hernandez A, Fernandez-Hidalgo O, et al. Leptomeningeal carcinomatosis: Prognostic value of clinical, cerebrospinal fluid, and neuroimaging features. Clin Neurol Neurosurg [Internet]. 2013;115(1):19-25. http://dx.doi.org/
10.1016/j.clineuro.2012.03.048
7. Odabasi Z, Parrott JH, Reddy VVB, Oh SJ. Neurolymphomatosis associated with muscle and cerebral involvement caused by natural killer cell lymphoma: A case report and review of literature. J Peripher Nerv Syst. 2001;6(4):197-203. https://doi.org/10.1046/j.1529-8027.2001.01018.x
8. Sakai N, Ito-Yamashita T, Takahashi G, Baba S, Koizumi S, Yamasaki T, et al. Primary neurolymphomatosis of the lower cranial nerves presenting as Dysphagia and hoarseness: a case report. J Neurol Surg Rep
[Internet]. 2014;75(1):e62-6. http://dx.doi.org/10.1055/s-0033-1363505
9. Finsterer J, Grisold W. Disorders of the lower cranial nerves. J Neurosci Rural Pract [Internet]. 2015;6(3):377. http://dx.doi.org/10.4103/0976-3147.158768
10. Toledano M, Siddiqui MA, Thompson CA, Garza I, Pittock SJ. Teaching NeuroImages: Diagnostic utility of FDG-PET in neurolymphomatosis.
Neurology. 2013;81(1):2013.http://dx.doi.org/10.1212/WNL.0b013e
318297eef5
11. Kimura J. Facts, fallacies, and fancies of nerve conduction studies: Twenty-first annual Edward H. Lambert lecture. Muscle and Nerve. 1997;20(7):777-87. http://dx. d o i . o rg/10 .1002/(SICI)1097-4598
(199707)20:73.0.CO;2-4
12. Leandri M. Trigeminal evoked potentials in cluster headache. 2000;43-6
13. Kimura J. The Blink Reflex. In: Electrodiagnosis in diseases of nerve and muscle: principles and practice. 2nd ed. Philadelphia: Oxford University; 1989. p. 307-31.
14. Morelli N, Mancuso M, Frittelli C, Falorni M, Gallerini S, Paolo DS, et al. Multiple cranial nerve palsies in testicular lymphoma: Report of a case. Neurologist [Internet].2007;13(4):222-4.
15. Mauermann ML. Neurologic Complications of Lymphoma, Leukemia, and Paraproteinemias. Contin Lifelong Learn Neurol [Internet]. 2017;23(3):669-90. http://dx.doi.org/10.1212/CON.0000000000000468
How to Cite
1.
Rivera AH, Barrera Castro SM. Brainsteem infiltration in advanced hematological malignancies; clinical features and diagnostic approach. Rev. Colomb. Med. Fis. Rehabil. [Internet]. 2019 Apr. 2 [cited 2024 May 16];28(2):126-32. Available from: https://revistacmfr.org/index.php/rcmfr/article/view/221
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Published
2019-04-02
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