Autonomic dysreflexia: Essential concepts from physical medicine and rehabilitation

Authors

DOI:

https://doi.org/10.28957/rcmfr.367

Keywords:

Spinal cord, spinal cord injuries, autonomic dysreflexia, rehabilitation, therapy

Abstract

Spinal cord trauma is common worldwide, causes an impact on functionality and generates a high rate of disability. It presents motor, sensory and additionally autonomic manifestations, the latter being an important cause of morbidity and mortality. Spinal cord injuries at levels higher than T6 can generate autonomic dysreflexia (AD), which manifests mainly with arterial hypertension and other autonomic symptoms, triggered by unmodulated sympathetic reflexes, released by a wide variety of visceral and somatic stimuli. The clinical manifestations of AD can generate additional complications to the clinical picture and even cause the death of the patient; for which it is of vital importance for health professionals to know the pathology, early identification and management of AD. In this article, a narrative review of AD is carried out with the aim of making its definition, pathophysiology, and management known.

References

Sabre L, Rekand T, Asser T, Kõrv J. Mortality and causes of death after traumatic spinal cord injury in Estonia. J Spinal Cord Med. 2013;36(6):687-694. Disponible en: http://doi.org/10.1179/2045772313Y.0000000120

K arlsson A . Autonomic dysref lexia. Spinal Cord. 1999;37(6):383-391. Disponible en: http://doi.org/10.1038/sj.sc.3100867

Eldahan KC, Rabchevsky AG. Autonomic dysref lexia after spinal cord injur y: Systemic pathophysiology and methods of management. Auton Neurosci. 2018;209:59-70. Disponible en: http://doi.org/10.1016/j.autneu.2017.05.002

Canon S, Shera A, Phan NMH, Lapicz L, Scheidweilwer T, Batchjelor L, et al. Autonomic dysreflexia during urodynamics in children and adolescents with spinal cord injury or severe neurologic disease. J Pediatr Urol. 2014;11(1):32.e1-32.e4. Disponible en: https://doi.org/10.1016/j.jpurol.2014.08.011

Lindan R, Joiner E, Freehafer AA, Hazel C. Incidence and clinical features of autonomic dysreflexia in patients with spinal cord injury. Spinal Cord. 1980;18(5):285-292. Disponible en: https://doi.org/10.1038/sc.1980.51

Hiekey KJ, Vogel LC, Willis KM, Anderson CJ. Prevalence and etiology of autonomic dysreflexia in Chiloren with spinal cord injuries. J Spinal Cord Med. 2004;27(Supl1):S54-S60. Disponible en: http://doi.org/10.1080/10790268.2004.11753786

Krassioukov AV, Furlan JC, Fehlings MG. Autonomic dysreflexia in acute spinal cord injury: An under-recognized clinical entity. J Neurotrauma. 2003;20(8):707-716. Disponible en: https://doi.org/10.1089/089771503767869944

Curt A, Nitsche B, Rodic B, Schurch B, Dietz V. Assessment of autonomic dysref lexia in patients with spinal cord injury. J Neurol Neurosurg Psych. 1997;62(5):473-477. Disponible en: http://doi.org/10.1136/jnnp.62.5.473

Furusawa K, Tokuhiro A, Sugiyama H, Ikeda A, Tajima F, Genda E, et al. Incidence of symptomatic autonomic dysreflexia varies according to the bowel and bladder management techniques in patients with spinal cord injury. Spinal Cord. 2011;49(1):49-54. Disponible en: http://doi.org/10.1038/sc.2010.94

Llewellyn-Smith IJ. Anatomy of synaptic circuits controlling the activity of sympathetic preganglionic neurons. J Chem Neuroanat 2009;38(3):231-239. Disponible en: http://doi.org/10.1016/j.jchemneu.2009.06.001

Tang FR, Tan CK, Ling EA. A light-microscopic study of the intermediolateral nucleus following injection of CB-HRP and fluorogold into the superior cervical ganglion of the rat. J Auton Nerv Syst 1995;50(3):333-338. Disponible en: http://doi.org/10.1016 0165-1838(94)00104-r

Thomas GD. Neural control of the circulation. Adv Physiol Educ. 2011;35(1):28-32. Disponible en: http://doi.org/10.1152/advan.00114.2010

Zhu H, Roth BL. Silencing synapses with DREADDs. Neuron. 2014;82(4):723-725. Disponible en: https://doi.org/10.1016/j.neuron.2014.05.002

Kirshblum S, Eren F, Solinsky R, Gibbs K, Tam K, DeLuca R, et al. Diastolic blood pressure changes during episodes of autonomic dysreflexia. J Spinal Cord Med. 2021;44(5):720-724. Disponible en: http://doi.org/10.1080/10790268.2020.1757273

Allen KJ, Leslie SW. Autonomic Dysreflexia. [Updated 2022 May 27]. En: StatPearls [Internet]. Treasure Island (FL): St atPearls Publishing; 2022 Enero. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK482434/

Krassioukov A, Warburton DE, Teasell R, Eng JJ, Spinal Cord Injury Rehabilitation Evidence Research Team. A systematic review of the management of autonomic dysreflexia after spinal cord injury. Arch Phys Med Rehabil. 2009;90(4):682–695. Disponible en: https://doi.org/10.1016/j.apmr.2008.10.017

Lockwood G, Durkee C, Groth T. Intravesical Botulinum Toxin for Persistent Autonomic Dysreflexia in a Pediatric Patient. Case Rep Urol. 2016;2016:4569684. Disponible en: https://doi.org/10.1155/2016/4569684

Grobecker H. Pharmacology and clinical pharmacology of organic nitrates. Eur J Clin Pharmacol. 1990;38(S1):S3-S7. Disponible en: https://doi.org/10.1007/BF01417558

Vallès M, Benito J, Portell E, Vidal J. Cerebral hemorrhage due to autonomic dysreflexia in a spinal cord injury patient. Spinal Cord. 2005;43(12):738-740. Disponible en: http://doi.org/10.1038/sj.sc.3101780

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-1252. Disponible en: https://doi.org/10.1161/01.HYP.0000107251.49515.c2

Furlan JC. Autonomic dysreflexia following acute myelitis due to neuromyelitis optica. Mult Scler Relat Disord. 2018;23:1-3. Disponible en: https://doi.org/10.1016/j.msard.2018.04.007

Phillips AA, Elliott SL, Zheng MMZ, Krassioukov AV. Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury. J Neurotrauma. 2015;32(6):392-396. Disponible en: https://doi.org/10.1089/neu.2014.3590

Harman KA, DeVeau KM, Squair JW, West CR, Krassioukov AV, Magnuson DSK. Effects of early exercise training on the severity of autonomic dysref lexia following incomplete spinal cord injury in rodents. Physiol Rep. 2021;9(15):e14969. Disponible en: http://doi.org/10.14814/phy2.14969

Eldahan KC. Targeting maladaptive plasticity after spinal cord injury to prevent the development of autonomic dysreflexia [Theses and Dissertations - Physiology - 41]. University of Kentucky; 2019. Disponible en: https://uknowledge.uky.edu/physiology_etds/41/

Jacobs PL, Nash MS. Exercise Recommendations for Individuals with Spinal Cord Injury. Sports Med. 2004;34:727–751. Disponible en: https://doi.org/10.2165/00007256-200434110-00003

Biering-Sørensen F, Biering-Sørensen T, Liu N, Malmqvist L, Wecht JM, Krassioukov A. Alterations in cardiac autonomic control in spinal cord injury. Auton Neurosci. 2018;209:4-18. Disponible en: https://doi.org/10.1016/j.autneu.2017.02.004

How to Cite

1.
Rangel Galvis CE, Álvarez Fajardo SY, Ramos Garavito JD. Autonomic dysreflexia: Essential concepts from physical medicine and rehabilitation. Rev. Colomb. Med. Fis. Rehabil. [Internet]. 2022 Dec. 23 [cited 2024 May 18];32:257-64. Available from: https://revistacmfr.org/index.php/rcmfr/article/view/367

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2022-12-23

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